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Problem: It is common to see nasal polyps arising from the lateral wall of the nose; however, polyps arising from the nasal septum are rare. Diagnosis of such lesions is usually made by nasal endoscopy and confirmed by computer tomography.
Methodology: Two cases of isolated nasal septum polyps were diagnosed from 150 consecutive functional endoscopic sinus surgeries. Both patients had septal deviation; only one had a history of allergy. The polyps were completely excised in both cases; the septal deviations were not corrected. Results: Both patients remain disease-free after two and three years of follow-up.
Conclusions: Nasal septal deviation does not seem to play an important role in septal polyp development, whereas local nasal inflammatory factors appear to be important for the genesis of septal polyps. Limited resection using a functional endoscopic surgical approach is the best choice of treatment to prevent recurrence of polyps.