Laryngeal cancer: smoking is not the only risk factor


1st ENT Department, University of Athens, Hippokrateion General Hospital, Athens, Greece


ENT Department, Lister Hospital, Stevenage, UK


2nd ENT Department, University of Athens, Attikon University Hospital, Athens, Greece


ENT Department, Evgenideion University Clinics, Athens, Greece

B-ENT 2012; 8: 273-278
Read: 759 Downloads: 597 Published: 12 February 2020

Laryngeal cancer: smoking is not the only risk factor. Aim: To investigate the role of smoking, alcohol, coffee consumption, demographic factors, toxic agents, and occupation in laryngeal carcinogenesis.

Materials/methods: A case-control study included 70 patients with histologically confirmed laryngeal cancer and 70 controls with non-neoplastic conditions unrelated to diet/smoking/alcohol. Relative risk, odds ratio (OR), and 95% confidence intervals were estimated using multiple logistic regression.

Results: Current smokers had 19.46 OR of laryngeal cancer compared to non-smokers (p = 0.006). The respective OR for alcohol consumption was 3.94 (p = 0.006). While the risk increased in heavy drinkers, there was no difference in duration of alcohol consumption. There was a strong and consistent relation between laryngeal cancer and the consumption of Greek/Turkish coffee cups/day (p = 0.002, OR = 1.77). Diesel exhaust fumes also seemed to increase the risk of laryngeal cancer, although the association was found to be no longer significant after analysis with logistic regression.

Conclusion: The present study confirmed the relation of smoking and alcohol with laryngeal cancer. However, other factors such as coffee and diesel exhaust fumes may play an important role in laryngeal carcinogenesis. EBM Level: III

EISSN 2684-4907