B-ENT
Case Report

Diffuse large B-cell lymphoma of the pterygopalatine fossa with multiple cranial nerve palsies

1.

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma

2.

Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Gunma

3.

Department of Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma

B-ENT 2021; 17: 196-200
DOI: 10.5152/B-ENT.2021.21585
Read: 553 Downloads: 431 Published: 12 November 2021

We report a case of diffuse large B-cell lymphoma (DLBCL) of the pterygopalatine fossa (PPF) that developed with multiple cranial nerve palsies. A 70-year-old woman received steroid treatment for right facial palsy but was referred to our hospital because of additional diplopia and dysarthria. Neurological examination revealed multiple cranial nerve palsies associated with the right IV and XII and bilateral VII nerves. Computed tomography and magnetic resonance imaging showed lesions infiltrating Meckel’s cavity and the cavernous sinus from the right PPF. Subsequently, right visual impairment and III and V1 cranial nerve palsies appeared; however, the right XII and left VII cranial nerve palsies improved spontaneously. A biopsy from the PPF was performed using an endoscopic transnasal approach, and the histological diagnosis was DLBCL. She was treated with chemotherapy. Although the PPF is an anatomically difficult site to access, biopsy using the endoscopic transnasal approach makes a minimally invasive diagnosis possible.

Cite this article as: Ida S, Matsuyama T, Ishizawa K, Nagashima K, Yoshida Y, Chikamatsu K. Diffuse large B-cell lymphoma of the pterygopalatine fossa with multiple cranial nerve palsies. B-ENT 2021; 17(3): 196-200.

Files
EISSN 2684-4907