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Calcified nodule in the buccal submucosa: a case report. A 34-year-old man developed an ovoid swelling in the right buccal submucosa adjacent to Stensen’s duct. Computed tomography revealed a 25 × 20 mm, well-demarcated calcified mass. The excised mass was encapsulated by soft tissues and contained a calcified nodule measuring 15 × 15 × 10 mm. Histopathologic examination revealed the absence of neoplastic cells. The peripheral wall of the mass was infiltrated by inflammatory cells and contained hemorrhages with minimal calcifications. The central portion of the mass was composed of foreign body granuloma-like changes and multiple calcified nodules that were diffusely hyalinized with fibrous connective tissue. The patient has been followed for six years with no recurrence. Accurate diagnosis is important to avoid unnecessary and mutilating surgery. To our knowledge, this is the first reported case of a calcified nodule in the buccal submucosa of an adult.